Differences in COVID-19 mortality in males and females: Is estrogen hormone attributing to sex differences?

Objectives: Globally, the case fatality ratio is more in males versus females. Some studies have suggested estrogen hormone decreases susceptibility to SARS CoV-2. We analyzed observed sex differences COVID-19 behavior and females clinical profiles of different age groups patients discussed their symptoms, laboratory evaluations, associated comorbidities. Material Methods: The were tested for through real-time RT-PCR (Reverse Transcription Polymerase Chain Reaction) assay. data obtained studied epidemiological, clinical, characteristics from medical records. Results: mortality rate was 12.33% (36/292) whereas 19.63% (84/428). In between group analysis, 8.7% (14/161) died <40 years 16.8% (22/131) than 40 males, 13.7% (21/153) 22.9%(63/275). women older greater younger emphasizing protection provided by them. proportion who expired due significantly differs cutoff years, X2 (1, n = 428). difference statistically significant at P < 0.05. Males are likely expire. Conclusion: Sex-related coronavirus pandemic been found pointing toward protective role other immunological Downregulation ACE2 expression, thereby reducing viral entry, might also be contributory decreasing